= sum of all reactions of the connective tissue prior to tissue damage. Inflammation is a vital reaction, ie bound to life.
causes
- busy organisms [fungi, worms, bacteria, viruses ,...]
-
allergens [foreign allergens, Car allergens] -
physical and chemical stimuli [poisons, Radiation ,...] -
foreign bodies [objects tumors ,...]
expiry of an inflammatory response
impairment (Functional laesa)
injurious action of a substance
tissue damage (Alteration)
Local reaction of the organism
Transient vasoconstriction the arterioles ("initial ischemia")
vasodilation of arterioles and formation of an active hyperemia (increased blood circulation by 10-fold)
REDNESS (rubor) / / WARMING (Calor)
enlargement of the lumen of the capillaries and venules
exudation (plasma leakage into the interstitium
)
SWELLING (tumor)
increasing the viscosity of the blood
(irritation of the nerve terminal)
PAIN (Dolor)
emigration of leukocytes from the vessels into the damaged Tissue ("chemotaxis" = attraction of leukocytes
phagocytosis of bacteria (or the like.) And tissue debris
regression with resorption of
exudate without tissue destruction
"restitution ad integrum" =
complete cure
progression in the continuance of
harmful effect / inflammatory response
proliferation
= formation of granulation tissue with capillary buds
scarring
(regression of the capillaries)
Common symptoms
-
leukocytosis with left shift -
increase in immunoglobulins -
fever as a sign of metabolic increase -
subjective fatigue and malaise
influences on the course of the inflammatory Reaction
-
type of inflammation caused -
duration of the injurious effect -
responsiveness and disease resistance of the affected organism
forms of inflammation
first serous inflammation
-
abundant protein-rich exudate -
-
much mucus
second fibrinous inflammation
-
accumulation of exudate with Fibrinmaterial -
at (mucus) skin -
formation of grayish-yellow pseudomembrane on the inflammatory area (eg diphtheria)
third purulent inflammation
-
little exudate -
enriched [thereby placing a proteolytic enzyme which leads to liquefaction of tissue] with leukocytes are going to be essentially fatty -
yellowish cream-like texture
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